Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

نویسندگان

  • Marta Bartoskova
  • Radka Dobsikova
  • Vlasta Stancova
  • Ondrej Pana
  • Dana Zivna
  • Lucie Plhalova
  • Jana Blahova
  • Petr Marsalek
چکیده

The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In the Subchronic Toxicity Test, a significant (P < 0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found. In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase. From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Histopathological Changes of Zebrafish (Danio rerio) Ovaries Exposed to Sub-lethal Concentrations of Methyl Paraben

Paraben compounds are used widely as preservatives to inhibit microbial growth and extend used in pharmaceuticals, hygienic, cosmetics, care products. They pose the potential for reproductive toxicity for users. This paper provides an overview of the applications of histopathological biomarkers in reproductive toxicity in zebrafish caused by methylparaben. The present study investigated the cha...

متن کامل

Investigation of Toxicological Effects of di-2-ethylhexyl with Fish Embryo Test (FET) in Zebrafish (Danio rerio)

Di(2-ethylhexyl)phthalate (DEHP) is a plasticizer in a variety of consumer products. Given the adverse toxicity effects of DEHP on living organisms, its high consumption and dispersal has been caused a serious concern. . Nowedays, the Fish Embryo Test (FET) method is widely used among the conventional methods of toxicology .The aim of the this study was to determine the acute toxicity of Di(2-e...

متن کامل

A review of the performance of zebrafish (Danio rerio) as a model organism in nanotoxicological research and its differences with other animal models

Today, nanotechnology is recognized as one of the leading sciences in the world, which manipulates atoms and molecules in order to produce valuable products. Extensive use of nanomaterials in various industrial sectors has increased the possibility of their diffusion in water bodies and the environment. Therefore, the study of toxicity of these substances is considered as one of the research ne...

متن کامل

Safety evaluation of chloramine –T on ornamental zebra fish (Danio rerio) using LC50 calculation and organ pathology

The need of aquarists for proper and safe disinfection of fish with Chloramine-T (CL-T) necessitates toxico/pathologic examinations.   This study assays toxicity level of CL-T and histopathologic changes of gills, liver, kidney and brain of treated zebrafish (Danio rerio). Groups of 10 Zebrafish were treated with 0 (control), 5, 10, 15, 30, 50,100 and 200 mg/L of CL– T. Mortality was recorded a...

متن کامل

Evaluation of of the performance of the zebrafish (Danio rerio) model in nanotoxicology studies with emphasis on embryo pathology

The present study was conducted to evaluate the performance of zebrafish (Danio rerio) as a model in embryo and fetal pathology in nanotoxicology studies. Examination of the sources showed that it is possible to completely inhibit hatching and fetal death when exposed to nanoparticles, because nanoparticles interact with hatching enzymes. Zebrafish embryo developmental abnormalities have been s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2014  شماره 

صفحات  -

تاریخ انتشار 2014